{"id":24,"date":"2022-03-18T16:33:46","date_gmt":"2022-03-18T15:33:46","guid":{"rendered":"http:\/\/www.congressi.unisi.it\/aicbmm\/?page_id=24"},"modified":"2025-02-18T16:27:00","modified_gmt":"2025-02-18T15:27:00","slug":"programme","status":"publish","type":"page","link":"https:\/\/www.congressi.unisi.it\/aicbmm\/programme\/","title":{"rendered":"Programme"},"content":{"rendered":"

6th<\/sup> AIC-BMM Meeting \u2013 Schedule and Scientific Program<\/strong><\/h3>\n\n\n
Printable version<\/a>Download<\/a><\/div>\n\n\n\n


THURSDAY, FEB 20TH<\/sup> 2025<\/strong><\/em><\/p>\n\n\n\n

13:00<\/strong> Participant registration and accommodation check-in. Appetizers & light lunch
14:30<\/strong> Welcome by AIC-BMM Committee<\/p>\n\n\n\n

AFTERNOON SESSION I
Molecular mechanisms in biological processes<\/strong>
Chair: Marco Mazzorana<\/p>\n\n\n\n

14:40<\/strong> Invited speaker: Daniele Narzi<\/strong>. Department of Physical and Chemical Sciences<\/em>, University of L’Aquila, Italy.<\/em>
Title: From Structure to Function: Integrating Theoretical Approaches to Elucidate the Catalytic Mechanism of Oxygen Evolution in Photosystem”

15:10 Noemi Destefani<\/strong>. Biocrystallography Unit, Division of Immunology, IRCCS San Raffaele Scientific Institute, Milan, Italy.<\/em>
Title: Antigen-mediated and cell-autonomous B-cell receptor signalling in chronic lymphocytic leukaemia:<\/p>\n\n\n\n

15:30 Lorenzo Antonelli<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR) and Department of Biochemical Sciences, University La Sapienza, Rome, Italy.<\/em>
Title: Deciphering the activation mechanism of Sigma 1 Receptor and the nature of its endogenous ligands.<\/p>\n\n\n\n

15:50 Alessandro Borsellini<\/strong>. Human Technopole, Milan, Italy<\/em>.
Title: Molecular mechanisms of condensin II activity.

16:10<\/strong> Coffee Break & Snack<\/p>\n\n\n\n

AFTERNOON SESSION II
Macromolecular structures as a strategy against infectious pathogens<\/strong>
Chair: Veronica Morea<\/p>\n\n\n\n

16:40<\/strong> Invited speaker: Adele Di Matteo<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR),
Rome, Italy.<\/em>
Title: Tackling Signaling Pathways in Pseudomonas aeruginosa<\/em> to Unveil Druggable Targets

17:10 C\u00e9cile Exertier<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR), Rome, Italy<\/em>.
Title: A proof-of-concept study for the design of PROTACs (PROteolysis TArgeting Chimeras) to tackle Leishmaniases.<\/p>\n\n\n\n

17:30 Mario Privitera<\/strong>. Institute of Biostructures and Bioimaging (IBB-CNR) and University of Campania Luigi Vanvitelli, Caserta, Italy<\/em>.
Title: Structural features of KP32 phage portal attacking Klebsiella pneumoniae cell wall. Integrating structural biology and AI to unravel a complex biological problem<\/p>\n\n\n\n

17:50 Valeria Napolitano<\/strong>. Institute of Biostructures and Bioimaging (IBB-CNR), Naples, Italy.<\/em>
Title: Structural basis of protein encapsulation in Klebsiella pneumoniae and applications against multi-drug resistant pathogens.<\/p>\n\n\n\n

18:10 Filippo Vascon<\/strong>. Department of Biology, University of Padua, Italy<\/em>.
Title: Deciphering the Bacterial SOS Response: From Structural Insights to Inhibitor Development.
<\/p>\n\n\n\n

18:30 Posters flash presentations<\/strong> – Chair: Stefano Mangani<\/p>\n\n\n\n

18:30 Bianca Braggiotti<\/strong>. Institute of Biophysics (IBF-CNR), Milan, Italy<\/em>.
Title: TRAF2 in TNF Signaling and Immune Regulation: Structural Insights and Therapeutic Potential in Cancer.
18:35 Vittorio Brufani<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR) and Department of Biochemical Sciences, University La Sapienza, Rome, Italy<\/em>.
Title: Investigating BiP\u2019s Function in the Regulation of S1R Activity.
18:40 Viviana Perrotta<\/strong>. Institute of Biostructures and Bioimaging (IBB-CNR), Naples, Italy.<\/em>
Title: Understanding PE_PGRS, cell wall proteins promoting mycobacterial survival in TB.
18:45 Chiara Marella D\u2019Aprile<\/strong>. Institute of Crystallography (IC-CNR), Bari, Italy<\/em>.
Title: Bacteriorhodopsin\/Perovskite adducts for Next-Generation of in-crystal lab-on-chip Solar Cells.
18:50 Martina D\u2019Auria<\/strong>. Department of Chemical Sciences, University of Naples Federico II, Italy.<\/em>
Title: A novel PET hydrolase derived from thermophilic microorganism.
18:55 Ornella Ghilardi<\/strong>. Institute of Biostructures and Bioimaging (IBB-CNR) and Department of Medical Biotechnologies, University of Siena, Italy.<\/em>
Title: Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross-opsonic antigen against Gram-positive nosocomial pathogens.
19:00 Federica Sonzini<\/strong>. Department of Biosciences, University of Milan, Italy.<\/em>
Title: The open dimeric conformation of cardiotoxic light chains: a key feature underlying soluble toxicity in cardiac AL amyloidosis.
19:05 Doriano Lamba<\/strong>. Institute of Crystallography, National Research Council, Trieste Outstation, Trieste, Italy.<\/em>
Title: Disentangling the mechanism underlying the covalent methanesulfonyl fluoride acetylcholinesterase adduct formation and evolvement: structural and mechanistic insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles
19:10 Arianna Lardieri<\/strong>. Department of Biochemical Sciences, University La Sapienza, Rome, Italy<\/em>.
Title: Cryo-EM structure of Apo-PdxR from Bacillus clausii in complex with its target DNA.
19:15 Louiza Moudoud<\/strong>. Biocrystallography Group, IRCCS San Raffaele Scientific Institute, Milan, Italy<\/em>.
Title: Thermal and Structural Characterization of Rv0678: Insights into Multidrug Resistance in Tuberculosis.
19:20 Patrizio Di Micco<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR), Rome, Italy<\/em>.
Title: Face2Face: A simple tool for macromolecule interfaces analysis.
19:25 Gianmarco Pascarella<\/strong>. Institute of Molecular Biology and Pathology (IBPM-CNR), Rome, Italy<\/em>.
Title: Consensus3D. A comprehensive pipeline for accurate detection of conserved protein regions based on structure alignment programs consensus.
19:30 Veronica Morea<\/strong>. Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR), Rome<\/em>
Title: Structure-based design of peptides for biomedical applications<\/p>\n\n\n\n

Conclusions of Day I<\/strong><\/p>\n\n\n\n

19:40<\/strong> Aperitif & appetizers<\/p>\n\n\n\n

20:30<\/strong> Social Dinner @ Ristorante Pizzeria San Domenico, Piazza S. Domenico, 11, 50014 Fiesole FI, Italia (www.pizzeriasandomenico.it\/<\/a>)<\/p>\n\n\n\n

FRIDAY, FEB 21ST <\/sup>2025<\/em><\/strong><\/p>\n\n\n\n

MORNING SESSION I
Drug development<\/strong>
Chair: Massimiliano Perduca<\/p>\n\n\n\n

9:00<\/strong> Invited speaker: Grzegorz Popowicz<\/strong>. Helmholtz Zentrum M\u00fcnchen \u2013 Deutsches Forschungszentrum f\u00fcr Gesundheit und Umwelt (GmbH), Munich, Germany<\/em>
Title: From AI crystallographer to AI drug designer? Where advanced computational tools can help us understand molecules.

9:30 Luisa Napolitano<\/strong>. Structural Biology Laboratory, Elettra Sincrotrone Trieste and Institute of Crystallography (IC-CNR), Trieste, Italy<\/em>.
Title: High Resolution Structure of StARD3 protein in complex with VS1 inhibitor.<\/p>\n\n\n\n

9:50 Elisa Fagnani<\/strong>. Institute of Biophysics (IBF-CNR), Milan, Italy<\/em>.
Title: Development of BIR1-targeting compounds for cancer treatment: study of IAPs modulation in NF-\u039aB pathway.<\/p>\n\n\n\n

10:10 Andrea Dalle Vedove<\/strong>. AREA Science Park and Protein Targets for Drug Discovery Lab, Elettra-Sincrotrone Trieste, Italy.<\/em>
Title: What\u2019s new in Elettra\u2019s Structural Biology Laboratory.<\/p>\n\n\n\n

10:30 James Parry<\/strong>. Unchained Labs<\/em>
Title: Meet the Aunty – Queen of Protein Stability

10:40<\/strong> Coffee Break & Snacks<\/p>\n\n\n\n

MORNING SESSION II
Large macromolecular complexes by integrated structural biology<\/strong>
Chair: Silvia Onesti<\/p>\n\n\n\n

11:00<\/strong> Invited speaker: Philipp Sebastian Herdmann<\/strong>. Human Technopole, Milan, Italy<\/em>.
Title: Towards a Biopsy at the Nanoscale.

11:30 Luca Mazzei<\/strong>. Department of Pharmacy and Biotechnology, University of Bologna, Italy.<\/em>
Title: Structural characterization of urease activity and inhibition: an integrated X-ray crystallography and cryo-EM study.<\/p>\n\n\n\n

11:50 Christian Buratto<\/strong>. Department of Chemical Sciences, University of Padua, Italy.<\/em>
Title: Ruthenium-based polyoxometalates as a possible chaperone in cryo-EM structure determination: a case study.<\/p>\n\n\n\n

12:10 Luca Broggini<\/strong>. Department of Biosciences, University of Milan, Italy.<\/em>
Title: Structural characterization of Atrial Natriuretic Peptide amyloid fibrils from Isolated Atrial Amyloidosis patients.<\/p>\n\n\n\n

12:30 Sofia De Felice<\/strong>. Department of Biology, University of Padua, Italy.<\/em>
Title: Structural and functional characterization of hyper-stable human serum albumin variants.

13:00<\/strong> Announcement of the AIC Prizes for six oral young participants<\/p>\n\n\n\n

13:15 <\/strong> Closing remarks & light lunch<\/p>\n","protected":false},"excerpt":{"rendered":"

6th AIC-BMM Meeting \u2013 Schedule and Scientific Program THURSDAY, FEB 20TH 2025 13:00 Participant registration and accommodation check-in. Appetizers & light lunch14:30 Welcome by AIC-BMM Committee AFTERNOON SESSION IMolecular mechanisms in biological processesChair: Marco Mazzorana 14:40 Invited speaker: Daniele Narzi. Department of Physical and Chemical Sciences, University of L’Aquila, Italy.Title: From Structure to Function: Integrating […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"saved_in_kubio":false,"footnotes":""},"class_list":["post-24","page","type-page","status-publish","hentry"],"kubio_ai_page_context":{"short_desc":"","purpose":"general"},"_links":{"self":[{"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/pages\/24","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/comments?post=24"}],"version-history":[{"count":9,"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/pages\/24\/revisions"}],"predecessor-version":[{"id":271,"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/pages\/24\/revisions\/271"}],"wp:attachment":[{"href":"https:\/\/www.congressi.unisi.it\/aicbmm\/wp-json\/wp\/v2\/media?parent=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}