Detailed final program pdf

Tuesday, July 5th 2022

14:00-18:00  Registration
16:00-18:05    BioTop Session

Session: BioTop
16:00-16:45 Functional diversity to expanding applications of auxiliary activity oxidoreductases
Emma Master

16:45-17:05 Common Ancestor Reconstruction As A Tool For Improving Thermostability Of Bacterial Pyranose Oxidases
Anja Kostelac, Leander Sützl, Dietmar Haltrich

17:05-17:25 Localization Of Pyranose 2-Oxidase Derived From Kitasatospora Aureofaciens: A Step Closer To Elucidate The Biological Role
L. Jessica Virginia and Clemens Peterbauer

17:25-17:45 Reavealing Lytic Polysaccharide Monooxygenase Catalysis On Solid Cellulosic Substrates
Lorenz Schwaiger, Florian Csarman, Hucheng Chang and Roland Ludwig

17:45-18:05 In Vivo Enzyme Cocktails For Lignin Depolymerization
Silja Välimets, Clemens Karl Peterbauer, Michael Sauer

Wednesday, July 6th 2022

8:30 Registration
8:45-9:00 Opening

9:00-9:45 Structure, Function And Application Of Lpmos – Unique Monocopper Peroxygenases For Biomass Processing And Beyond
Vincent G.H. Eijsink

Session: Biotech Appl. – Oxizymes in Biorefinery
Chair: Rebecca Pogni, Angel Martinez

9:45-10:05 Recombinant Expression Of Polyphenol Oxidase Mtppo7 From Myceliophthora Thermophila To Fuel Lytic Polysaccharide Monooxygenase Action
Caio de Oliveira Gorgulho Silva, Jane W. Agger, Willem J.H. van Berkel, Mirjam A. Kabel, Anne S. Meyer

10:05-10:25 New Findings With Fungal Lytic Polysaccharide Monooxygenases
Peicheng Sun, David Cannella, Leila Lo Leggio, Roland Ludwig, Willem van Berkel, Mirjam A. Kabel

10:25-10:45 Investigating Lytic Polysaccharide Monooxygenase’s Wood Cell Wall Mechanism With Microbiosensors
Roland Ludwig, Hucheng Chang, Neus Gacias-Amengual, Alexander Botz, Lorenz Schwaiger, Daniel Kracher, Stefan Scheiblbrandner, Florian Csarman

10:45-11:15  Coffee Break

Session: Biotech Appl. – Oxizymes in Biorefinery
Chair: Ligia Martins, Sergio Riva

11:15-11:45 New Fungal Peroxygenase For Epoxides Production From Vegetable Oil: Structural Characterization, Protein Redesign And Process Optimization 
Linde D, González-Benjumea A, Santillana E, Carro J, Aranda C, Fernández-Fueyo E, Romero A*, Gutiérrez A2, Martínez AT

11:45-12:05 Enzyme Engineering Driven By Distal Mutations And Machine Learning
Lur Alonso Cotchico, Ryoji Takahashi, Marina Cañellas, Emanuele Monza, Maria Fatima Lucas

12:05-12:25 Cazy Aa3 Carbohydrate Active Dehydrogenases For Upgrading Xylooligosaccharides To Added-Value Materials
Hongbo Zhao, Johanna Karppia,  Emma Master, Maija Tenkanen

12:25-12:45 Tandem lignin polymerization/depolymerization by bacterial laccases towards lignin nanofibers and nanoparticles
Claudia Crestini

12:45-13:05 Lytic Polysaccharide Monooxygenases Activity And Substrate Specificity: An Atr-Ftir Assay Tested On A New Ppaa10
Giulia Di Rocco, Ilenia Serra, Daniele Piccinini, Alessandro Paradisi,Carlo Augusto Bortolotti, Gianantonio Battistuzzi,  Marco Sola

13:05-14:30   Lunch & Posters

Session: Biotech/Biomaterials
Chair: Yasmina Mackmouche, Giovanni Sannia

14:30-15:00 Extremophilic Laccases Engineered By Directed Evolution For Kraft Pulp Biorefineries And Fibreboard Manufacture
Susana Camarero, David Rodríguez-Escribano, Rocío Pliego, Felipe de Salas, Pablo Aza, Valérie Meyer, Michel Petit-Conil, Sandra Tapin-Lingua, Michael Lecourt,  Marta Pérez-Boada and Angel T. Martínez

15:00-15:20 Laccase-Based Improvement Of Lignocellulosic Fibres Properties
Filippo Fabbri, Michael Cordin, Tung Pham and Georg M. Guebitz

15:20-15:40 Coupling Oxidoreductases With Electrodes For Biosensing, Biofuel Cells, And Biocatalysis Applications
Omer Yehezkeli

15:40-16:00 Use of Laccases for the Functionalization of Technical Lignins
Sebastian A. Mayr, Raditya Subagia, Renate Weiß, Nikolaus Schwaiger, Johannes Leitner, Janez Kovač, Doris Ribitsch, Gibson S. Nyanhongo, Georg M. Guebitz

16:00-16:20 Short Coffee Break

Session: Biotech/Biomaterials
Chair: Selin Kara, Willem van Berkel

16:20-16:40 Role Of Loops Around The Active Site In Dye-Decolorizing Peroxidase Kadypa2 
Enikő Hermann, Carolina F. Rodrigues, Peter Herzog, Lígia O. Martins, Chris Oostenbrink, Clemens K. Peterbauer 

16:40-17:00 H2O2-Free Electrochemical Operation Of Class P And I Dye Decolorizing Peroxidases: Mechanistic Insigths
Magalí F. Scocozza, Francisco Vieyra, Carolina F. Rodrigues, Lígia O. Martinsand Daniel H. Murgida 

17:00-17:20 Surface Enhanced Resonance Raman View Of The Active Site Architecture In Dyps – The Search For (Dis)Functional Immobilized Enzymes
Smilja Todorovic, Catarina Barbosa, Celia M. Silveira, Nikola Lončar, Marco Fraaije, and Ligia O. Martins

17:20-17:40 Oxizymes For Functional Coating Of Agrochemical
Renate Weiß, Sebastian Gritsch, Günter Brader, Branislav Nikolic, Marc Spiller, Julia Santolin, Hedda K. Weber, Nikolaus Schwaiger, Sylvain Pluchon, Kristin Dietel, Georg Gübitz, Gibson Nyanhongo

17:40-18:00 Laccase Polymerized Lignin Can Improve The Wet Resistance Of Starch-Based Glues
Miguel Jimenez Bartolome, Nikolaus Schwaiger, Rene Flicker, Bernhard Seidl, Martin Kozich, Gibson S.Nyanhongo, Georg M.Guebitz

18:00-18:30 Meeting of the Scientific Committee

19:00 Welcome Cocktail (Rectorate)

Thursday, July 7th 2022

Session: Biotech Applications
Chair: Cinzia Pezzella, Roland Ludwig

8:45-9:30 Flavoprotein Oxidases For Plant Biomass Valorization
Marco Fraaije

9:30-9:50 A Three-Enzyme Cascade For The Self-Sustained Production Of Fatty-Acid Epoxides From Vegetable Oils
Juan Carro, Ángel T. Martínez

9:50-10:10 The Fusion Protein Fdhc23s+AzoRo As An In Situ Fuel For H2O2-Dependent Reactions
Anna Christina R. Ngo, Abdulkadir Yayci, Julia E. Bandow, Martin Weissenborn, Frank Hollmann, and Dirk Tischler

10:10-10:30 Selective Hydroxylation Catalysed By Unspecific Peroxygenase From Agrocybe Aegerita 
Yinqi Wu, Caroline E. Paul, Miguel Alcalde, and Frank Hollmann

10:30-10:50 Unlock New Biocatalysis – Oxyfunctionalization Via Unspecific Peroxygenases
Hannah Braß, David Schönauer

10:50-11:20   Coffee Break

Session: Newly discovered oxizymes
Chair: Claudia Crestini, C. K. Peterbauer

11:20-11:50 Lifestyle Evolution And Peroxidase Diversity In Agaricales As Revealed By Comparative Genomics 
FJ Ruiz-Dueñas, JM Barrasa, MI Sánchez-Ruiz, I Ayuso-Fernández, M Sánchez-García, S Camarero, S Miyauchi, A Serrano, D Linde, R Babiker, J Rencoret, I Davó-Siguero, E Drula, R Pacheco, G Padilla, P Ferreira, J Barriuso, H Kellner, R Castanera, M Alfaro, L Ramírez, AG Pisabarro, R Riley, A Kuo, W Andreopoulos, K LaButti, J Pangilinan, A Tritt, A Lipzen, G He, M Yan, A Gutiérrez, A Romero, V Ng, IV Grigoriev, D Cullen, F Martin, M-N Rosso, B Henrissat, D Hibbett, AT Martínez

11:50-12:10 Identification Of An Oligosaccharide Dehydrogenase From Pycnoporus Cinnabarinus Provides Insights Into Fungal Breakdown Of Lignocellulose
Giuliano Sciara, Gabriele Cerutti, Elena Gugole, Jean-Lou Reyre, Linda Celeste Montemiglio, Annick Turbé‑Doan, Dehbia Chena, David Navarro, Anne Lomascolo, François Piumi, Cécile Exertier, Ida Freda, Jean-Guy Berrin, Bastien Bissaro, Beatrice Vallone, Eric Record, Carmelinda Savino

12:10-12:30 Tandem Metalloenzymes Gate Plant Cell Entry By Pathogenic Fungi
Bastien Bissaro, Sayo Kodama, Takumi Nishiuchi, Anna Maria Díaz-Rovira, Hayat Hage, David Ribeaucourt, Mireille Haon, Sacha Grisel, A. Jalila Simaan, Fred Beisson, Stephanie M. Forget, Harry Brumer, Marie-Noëlle Rosso, Victor Guallar, Richard O´Connell, Mickaël Lafond, Yasuyuki Kubo and Jean-Guy Berrin

12:30-12:50 Cephalochordata Heme Peroxidases – A Peculiar Evolutionary Clade Between Thyroid Peroxidases And Peroxidasins
Marcel Zámocký, Jana Harichová, Paul G. Furtmüller

12:50-14:30  Lunch & Posters

Session: Oxizymes  Engineering & Biomimetic
Chair: Susanna Camarero, Georg Guebitz

14:30-15:00 Allosteric Mutations Shape Substrate-Binding Sites During Evolution Of A Metallo-Oxidase Into a Laccase 
Lígia O. Martins, Vânia Brissos, Patrícia T. Borges, Reyes Núñez-Franco,Maria Fátima Lucas,Carlos Frazão, Emanuele Monza, Laura Masgrau, Tiago N. Cordeiro

15:00-15:20 Influence Of The H98y Mutation On The Redox Reactivity Of Myoglobin And Its Role In The Onset Of Myoglobinopathy, A Newly Discovered Molecular Disease
Gianantonio Battistuzzi, Carlo Augusto Bortolotti, Stefan Hofbauer, Marcello Pignataro, Giulia Di Rocco, Paul G. Furtmuller, Gianina Ravenscroft, Marco Borsari, Christian Obinger, Marco Sola

15:20-15:40 Exploration Of Extant And Ancestral Sequence Space Of L-Lactate Oxidase
Leander Sützl, Lidiia Tsvik, Dominik Künig, Dietmar Haltrich

15:40-16:00 Supported Pd Oxidase Hybrid Catalysts For Aerobic Alcohol Oxidation
Fangfang Yang, Pierre Rousselot-Pailley, Cendrine Nicoletti, A.Jalila Simaan, Michel Giorgi, Bruno Faure, Elise Courvoisier-Dezord, Agnès Amouric, Yolande Charmasson, Rénal Backov, Thierry Tron and Yasmina Mekmouche

16:00-16:20  Short Coffee Break

Oxizymes  Engineering & Biomimetic
Chair: Anna Wilkolaska, Roland Ludwig

16:20-16:40 Molecular Lego As A Tool To Modulate The Stability And The Activity Of Human Cytochrome P450
Gianluca Catucci, Alberto Ciaramella, Giovanna Di Nardo, Chao Zhang, Silvia Castrignanò and Gianfranco Gilardi

16:40-17:00 Horseradish Peroxidase-Mimicking Dnazymes For Protein Modification
Jordi F. Keijzer, Bauke Albada

17:00-17:20 Virus-Based Enzymatic Nanoreactor For Breast Cancer Treatment
Kanchan Chauhan and Rafael Vazquez-Duhalt

17:20   Sophie Vanhulle Prize
Chair: Giovanni Sannia
The ambivalent green role of laccase: from the production of bioinks to the design of de-inking systems
Eliana Capecchi, Valeria Gigli, Davide Piccinino, Daniele Avitabile and Raffaele Saladino

20:30 Gala Dinner (San Francesco cloister)

Friday, July 8th 2022

Session: Oxizymes in fine chemistry
Chair: Alonso Cotchico Lur, Sergio Riva

8:45-9:30 Biocatalytic Oxidations Using Oxygen From Screening To Pilot Plant Scale: Safe, Selective And Efficient
Martin Schürmann

9:30-9:50 Tunable Production Of (R)- Or (S)‑Citronellal From Geraniol Using A Copper Radical Alcohol Oxidase And Old Yellow Enzyme
David Ribeaucourt, Georg T. Höfler, Mehdi Yemloul, Bastien Bissaro, Fanny Lambert, Jean-Guy Berrin, Mickael Lafond, Caroline E. Paul

9:50-10:10 Chemoenzymatic Cascades For The Enantioselective Synthesis Of Β-Hydroxysulfides Bearing A Stereocentre At The C−O Or C−S Bond By Ketoreductases
Fei Zhao,Kate Lauder, Siyu Liu, James D. Finnigan, Simon B. R. Charnock, Simon J. Charnock,Daniele Castagnolo

10:10-10:30 P450 Monooxygenase Family Cyp153 As Promiscuous Catalysts: Substrate And Reaction Scope
Fabian Schultes, Carolin Mügge, Dirk, Tischler

10:30-10:50 Metal affinity enzyme (co-)immobilization for batch and continuous flow biocatalysis
Álvaro Cruz-Izquierdo, Alessandra Basso, Simona Serban

10:50-11:20 Coffee Break/Lunch

Session: Oxizymes in fine chemistry
Chair: Rafael Vazquez-Duhalt, Emma Master

11:20-11:50 Biocatalytic And Chemo-Enzymatic Cascades For The Synthesis Of Heterocycles And Sulfur Compounds By Oxidoreductase Enzymes
Daniele Castagnolo

11:50-12:10 Enzyme Engineering And Synthetic Applications Of Amine Dehydrogenases
Francesco G. Mutti, Tanja Knaus, Marcelo F. Masman, Vasilis Tseliou, Maria L. Corrado, Wesley Böhmer, Jan Vilím, Joseline A. Houwman, Magda Costa, Don Schilder

12:10-12:30 A Use Case On Unspecific Peroxygenase-Catalyzed (Photo)Biocatalytic Hydroxylations In Non-Conventional Media
Markus Hobisch, Piera De Santis, Miguel Alcalde, Chan Beum Park, Frank Hollmann, and Selin Kara

12:30-12:50 Cytochrome P450-Driven Hydroxylation Towards Medium-Chain Glycols
Carolin Mügge, Fabian Peter Josef Schultes, Myra Schmidtke

12:50-13:10 Fungal Aa5_2 Copper Radical Oxidases: From Exploration To Application
David Ribeaucourt, Maria Cleveland, Yann Mathieu, Bastien Bissaro, Victor Guallar, Georg T. Höfler, Mehdi Yemloul, Mireille Haon, Sacha Grisel, Véronique Alphand, Harry Brumer, Caroline E. Paul, Fanny Lambert, Jean-Guy Berrin and Mickael Lafond

13:10 Closing remarks

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