Schedule
Monday, June 7th 2021
10:20 Welcome by AIC-BMM Committee
10:30 Morning Session I
Protein small molecule interactions – Structure Based Drug design
Chair: Cecilia Pozzi – Università di Siena – IT
Invited speaker:
Alice Douangamath – Diamond Light Source – UK
Addressing COVID-19 With Fragment- Based Drug Discovery
11.00 Selected talks
Theo Battista – Sapienza Università di Roma – IT
Anti-trypanosomatidal drug discovery: a challenge for structural biology
Giovanni Bisello – Università di Verona – IT
Human Aromatic L-Amino Acid Decarboxylase (AADC) in its native and inhibitor bound crystal structure solved at different pH values
11.40 Break
11.50 Selected talks
Marta Ferraroni – Università di Firenze – IT
Structural insights into Schistosoma mansoni Carbonic Anhydrase Inhibition
Francesca Paoletti – National Institute of Chemistry Ljubljana – SLO Endogenous Modulators of Neurotrophin Signaling: Landscape of the Transient ATP- NGF Interactions
Simona Fermani – Università di Bologna – IT
Plant GADPH is primed to form globular insoluble aggregates by specific cysteine glutathionylation
12:50 Invited speaker Società Italiana Luce di Sincrotrone (SILS)
Michele Cianci – Università Politecnica delle Marche, Ancona – IT
The synergy between SILS and AIC-BMM: a personal perspective
14:30 Afternoon Session II
Macromolecular complexes – Protein-protein – Protein-nucleic acid
interactions
Chair: Sebastiano Pasqualato – Istituto Europeo di Oncologia, Milano – IT
Invited speaker
Filippo Mancia – Columbia University – USA
Structural basis of Wnt secretion by its carrier WLS
15:00 Selected talks
Ludovica Lopresti – Università di Siena – IT
Structural insight into YAP-TEAD4 protein- protein interactions as target for cancer treatment
Cristina Renna – Istituto Europeo di Oncologia, Milano – IT
The protein NuMA acts as amitotic dynein/dynactin adaptor
Stefano Ricagno – Università di Milano – IT
Structural bases of Light Chain Amyloidosis: the role of the native and the fibrillar states
16.00 Break
16:10 Selected talks
Marta Semrau – Sincrotrone Elettra Trieste e Università di Trento – IT
Structural characterization of the PTG and PTG/PP1 complex
Vincenzo Taibi – Fondazione Istituto FIRC di Oncologia Molecolare – IT
Structural insight of polyubiquitin chain formation mediated by NEDD4 HECT ligase
Sharon Spizzichino – Università La Sapienza di Roma – IT
Structural clues of serine hydroxymethyltranferase (SHMT) riboregulation
17:10 Invited speaker Società Italiana di Biofisica Pura e Applicata (SIBPA)
Francesco Spinozzi – Università Politecnica delle Marche – IT
SIBPA and AIC-BMM: perspectives for collaborative research
Tuesday, June 8th 2021
10:00 Morning Session III
Structures of Membrane proteins or Large Macromolecular Complexes, CryoEM
Chair: Linda Celeste Montemiglio – Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Roma – IT
10:05 Invited speaker
Stefan Kochanek – University of Ulm – DE
Interaction of Huntingtin and HAP40: what we know (little) and what we don’t know (much)
10:35 Selected talks
Pietro Roversi – Leicester Institute of Structural and Chemical Biology – UK and Consiglio Nazionale delle Ricerche Milano – IT
Towards the CryoEM structure of EDEM:PDI, the endoplasmic reticulum associated degradation glycoprotein misfolding checkpoint
Alessandro Grinzato – ESRF Grenoble – FR and Università di Padova – IT
CryoEM structure of tetanus neurotoxin in complex with two monoclonal antibodies that interfere with toxin binding and translocation into neurons
Francesco Margheriti – Scuola Normale Superiore di Pisa – IT
CryoEM analysis of membrane NAPE-PLD associated to nanodiscs
11:35 Break
11:45 Invited speaker
Martino Bolognesi – Università di Milano – IT
Mapping gating structural transitions and ion permeation in the HCN4 pacemaker channel
12:15 Invited speaker
Giuseppe Zanotti -Università di Padova -IT
Cryo-electron microscopy of Campylobacter jejuni serine protease HtrA
14:30 – 15:45 Round Table
New infrastructures for Italian structural biology research
Chair: Andrea Ilari – Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Roma – IT
15:45 Afternoon Session IV
Computational Methods – Structural Bioinformatics
Chair: Danilo Benny Belviso – Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Bari – IT
15:50 Invited speaker Società Italiana di Bioinformatica (BITS)
Anna Marabotti – Università di Salerno – IT
Prediction of protein structure: The ultimate solution lies Deep (in) Mind
16:20 Selected talks
Nicole Balasco – Institute of Biostructures and Bioimaging, Consiglio Nazionale delle Ricerche, Napoli – IT
Unraveling the determinants of the conformational preferences of amino acid residues: the role of the local geometry
Gianluca Santoni – European Synchrotron Radiation Facility, Grenoble -FR
The coronavirus structural taskforce
17:00 Invited speaker
James Fraser – University of California, San Francisco – USA
Targeting COVID-19 Viral Enzymes in an Evolving Landscape of Publishing and Peer Review
Wednesday, June 9th 2021
10:00 Morning Session V
Cool & hot structures – Difficult Cases – Disordered Proteins
Chair: Rocco Caliandro – Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Bari – IT
10:05 Invited speaker
Rita Berisio – Istituto di Biostrutture e Bioimmagini CNR – IT
Cell wall degrading enzymes against challenging antimicrobial resistant infectious pathogens
10:35 Selected talks
Danilo Benny Belviso – Istituto di Cristallografia, Consiglio Nazionale delle Ricerche Bari – IT
Structural characterization of C-terminal domain of NSD2 and NSD3 proteins by Small-Angle X-ray Scattering
Gabriele Giachin – Università di Padova – IT
Conformational selection mechanisms in human prion protein mutants bound to a therapeutic nanobody
11:15 Break
11:25 Invited speaker
Roberta Pierattelli – Università di Firenze – IT
Just flexible linkers?
11:55 Selected talks
Sonia Covaceuszach – Institute of Crystallography, Consiglio Nazionale delle Ricerche, Trieste Outstation – IT
A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions
Elisa Costanzi – Sincrotrone Elettra – TS
Elettra against COVID-19: Joint forces within “Exscalate4COV” project
12:35 Invited speaker
Annie Heroux – Sincrotrone Elettra – IT
Remote access at Elettra: XRD2 Beamline – MX home delivery
13:00 Prize for Best Young Crystallographer presentation andConcluding remarks by AIC-BMM Committee